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In the SURMOUNT-5 trial (NEJM, 2025), tirzepatide reduced body weight by 20.2% versus 13.7% for semaglutide over 72 weeks

Chenglai Xia, [email protected] These authors have contributed equally to this work This article was submitted to Cardiovascular and Smooth Muscle Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Results could significantly influence preventive cardiology for non-diabetic patients