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Skin changes appear (peau d'orange, hyperkeratosis, fibrosis)

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The AUCs with their 95% confidence interval (CI) were used to assess the individual discriminative accuracy of the differentially abundant metabolites and their ratio

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This is where medications like Semaglutide (Ozempic/Wegovy) and Tirzepatide (Mounjaro/Zepbound) enter the conversation