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In the hindbrain, the dorsal-vagal-complex (DVC), collectively comprised of the nucleus tractus solitarius (NTS), area postrema (AP) and dorsal motor nucleus of the vagus (DMV), mediates the anorectic effects of both amylin and GLP-1 receptor agonists 15,16,17,18,19
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doi: 10.1038/s41598-019-49613-z 93 WangWChuHYZhongZMQiXChengRQinRJet al
- In SURMOUNT-2, people taking Zepbound at the 15 mg dose experienced average weight reductions of 15.7% (34.4 pounds) and people taking Zepbound at the 10 mg dose experienced average weight reductions of 13.4% (29.8 pounds) compared to placebo 3.3% (7.0 pounds)
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