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One drug is available for clinical use, while the other is still in clinical trials

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Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine

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Specifically, GLP-1RAs appear to exert a direct protective effect on the liver by enhancing hepatic insulin sensitivity by activating the PI3K/Akt signaling pathway, which promotes glucose uptake while reducing gluconeogenesis [46]