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The accumulation of long-chain fatty acids within mitochondria impairs PDH activity, reducing glucose oxidation and increasing lactate and proton levels, which worsens myocardial injury
10.3390/md23010009 Mar
Long-term effects on insulin sensitivity remain under investigation
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Further investigation is required to examine the role that metabolism-dependent genetic mechanisms play in the development of depression and whether these mechanisms can have effects similar to those of antidepressants
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