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Acknowledgments We would like to thank the authors of these original studies on this topic included in our review

In high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice model and HK-2 cells, after treatment with metformin (200 mg/kg/d) for 24 weeks, some indicators of mitophagy (LC3II, Pink1, Parkin, Atg5) were examined

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Besides improving complexion, the injections are beneficial for a range of skin issues so as to make it more fresh and glowing

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