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This O 2 surge oxidizes the PDX-1 transcription factor, suppressing insulin gene expression [342], while simultaneously activating the IRE1-JNK pathway to trigger -cell apoptosis [343]
To become "reduced" (active) again so it can go back to work, it needs an electron from NADPH
Pharmacotherapy for non-alcoholic fatty liver disease: emerging targets and drug candidates
N Engl J Med 2009
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