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A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)
GHK-Cu (glycyl-L-histidyl-L-lysine copper(II)) addresses ageing through the Nrf2-antioxidant axis targeting the accumulated oxidative damage that produces mitochondrial dysfunction, lipid peroxidation, and inflammatory SASP in post-mitotic tissues
This is rare with medically supervised, appropriately dosed treatment courses but underscores why baseline liver function assessment is important before starting
Restoring testosterone to a healthy range can improve mood, focus, and overall motivation
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