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The best clinical result was 2.6 kilograms over 12 weeks, roughly 5.7 pounds

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Suicidal ideation was found to resolve after discontinuing the drugs in over 50% of patients

This is by design Allaras model defers all clinical assessment to post-enrollment provider visits and lab testing, where OBGYNs and registered dietitians conduct a thorough evaluation

However, full catabolism of ADCs with non-cleavable linkers structurally modifies the payload, which can negatively affect the activity of the payload 6