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Initial treatments may require several injections per week, followed by maintenance doses every month

The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant

Niacin can also have an antagonistic effect on gout medications: it elevates uric acid levels, which may counteract drugs like allopurinol or pegloticase that are meant to lower uric acid

Improved Skin, Hair, and Nails : B12 promotes cell growth and repair, benefiting the skin, hair, and nails