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Notoriously, both GIP-R agonists and antagonists lead to weight loss mainly when co-administrated with GLP-1 agonists or analogues
This dose-response relationship across receptor activation suggests that the more pathways you stimulate, the higher the likelihood of neurological side effects including skin sensitivity
Additionally, the intracellular GSH level changes measured using RT were confirmed by cell lysate-based liquid chromatographymass spectrometry (LCMS) measurements (Fig
10.1007/s00441-019-03016-8 26 HedenstiernaG.LarssonA
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